https://jamanetwork.com/journals/jama/article-abstract/2730114
Authors:
Singal G, Miller PG, Agarwala V, Li G, Kaushik G, Backenroth D, Gossai A, Frampton GM, Torres AZ, Lehnert E, Bourque D, O’Connell C, Bowser B, Caron T, Baydur E, Seidl-Rathkopf K, Ivanov I, Alpha-Cobb G, Guria A, He J, Frank S, Nunnally A, Bailey M, Jaskiw A, Feuchtbaum D, Nussbaum N, Abernethy AP, Miller VA.
Question Can clinical and genomic data obtained in routine clinical care be linked in a Health Insurance Portability and Accountability Act–compliant manner to yield clinically relevant insights?
Findings A deidentified database of 28 998 patients with cancer, approximately 85% of whom were treated in a community setting, was generated by linking electronic health record–derived longitudinal clinical data with comprehensive tumor genomic profiling. Analysis of 4064 patients with non–small cell lung cancer revealed clinical, genomic, and therapeutic associations that were consistent with prior reports and extended previous observations on evolving community practice patterns.
Meaning Using data obtained from routine clinical care to generate a validated, multi-institution clinicogenomic database is feasible and can yield novel, clinically meaningful insights.
Sources:
JAMA