Overview
This study utilizes electronic health record (EHR)-derived data from Germany and the UK in the Flatiron Health Research Database to examine patient characteristics and treatment patterns for patients with diffuse large B-cell lymphoma (DLBCL). The Flatiron Health Research Database is a longitudinal, deidentified database using structured and unstructured data accessed via technology-enabled abstraction from EHRs across oncology practices. The dataset undergoes rigorous quality checks, is anonymized per local regulations, and updated with 90-day recency.
By analyzing data of over 1,000 patients, the research highlights regional variations in patients and care, revealing differences in therapeutic approaches, including treatment regimens and biomarker testing. The findings also highlight the importance of international collaboration in understanding and addressing the challenges of managing DLBCL.
Why this matters
DLBCL is a common and aggressive form of lymphoma, new treatment options evolved recently in first and later lines. This study emphasizes the benefit of pan-European real-world data to inform and optimize treatment guidelines and contributes to the development of evidence-based treatment protocols. As additional patients accrue, further analysis on survival, treatment response and care gaps will be critical.