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Real-world insights into breast cancer in the UK: Findings from UK EHR-derived data

Published

October 2025

Citation

Samani A, Ali M, Sujenthiran A, Adamson B Real-world insights Into breast cancer in the UK: Findings from UK EHR-derived data . ISPOR Europe. 2025.

Overview

Comprehensive data on breast cancer are crucial for generating real-world evidence to understand the varying presentation and progression patterns that influence treatment decisions and patient outcomes. This study introduces a comprehensive dataset from the UK Flatiron Health Research Database, which captures detailed clinical information on breast cancer patients. 

By analyzing data from 2844 patients diagnosed with breast cancer, the study provides insight into key clinical variables, including histology, biomarker status, and recurrence status. The EHR-derived dataset enables a more comprehensive understanding of disease trajectories beyond what is typically captured in clinical trials.

Why this matters

This research fills critical gaps in existing breast data by offering a detailed view of real-world treatment and outcomes in the UK. The ability to harmonize this dataset with international counterparts from the US, Germany, and Japan allows for a global perspective on breast cancer management. Such comprehensive data supports the development of personalized treatment strategies and highlights areas for improvement in clinical practice and paves the way for more effective interventions worldwide.

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